What is 1,3-Benzenediol
1,3-Benzenediol, also known as resorcin or m-hydroquinone, belongs to the class of organic compounds known as resorcinols. Resorcinols are compounds containing a resorcinol moiety, which is a benzene ring bearing two hydroxyl groups at positions 1 and 3. 1,3-Benzenediol exists in all living organisms, ranging from bacteria to humans. 1,3-Benzenediol is a creamy, hawthorn, and musty tasting compound. 1,3-Benzenediol has been detected, but not quantified, in several different foods, such as alcoholic beverages, cereals and cereal products, coffee and coffee products, eggplants, and java plums. This could make 1,3-benzenediol a potential biomarker for the consumption of these foods. 1,3-Benzenediol is a potentially toxic compound. In addition, exogenous ochronosis is associated with prolonged exposure to resorcinol . Data regarding the specific mechanisms of action of resorcinol does not appear to be readily accessible in the literature. Nevertheless, the role played by iodide ions in the irreversible inactivation of the enzymes is not yet fully elucidated . Resorcinol works by helping to remove hard, scaly, or roughened skin. In particular, it appears that resorcinol indicated for treating acne, dermatitis, or eczema in various skin care topical applications and peels revolves around the compound's ability to precipitate cutaneous proteins from the treated skin . In LPO and TPO, the resulting π-cation radical of the porphyrin can isomerize to a radical cation with the radical in an aromatic side chain of the enzyme . In vitro and in vivo studies have demonstrated that resorcinol can inhibit peroxidases in the thyroid and subsequently block the synthesis of thyroid hormones and cause goiter .
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Used in organic synthesis to prepare various ether derivatives; used for printing drawings; analytical reagents. Soluble in water, alcohol, ether, benzene and carbon disulfide. Can be sublimated. reacts with ferric chloride to produce blue-violet color.
4-AMINODIPHENYLAMINE DYE INTERMEDIATES
4-AMINODIPHENYLAMINE: Dye intermediates. Mainly used to manufacture various important antioxidants such as 4010NA, 4020 and 668; to manufacture blue salt RT, acidic red GR, dispersed yellow GFL, etc.
2,6-Dihydroxytoluene, also called 2-Methylresorcinol in English. It is a white solid under normal circumstances. It has a certain Chemicalbook solubility in water and its aqueous solution is acidic. Soluble in common organic solvents. 2,6-Dihydroxytoluene is a phenolic compound that can be used as an intermediate in organic synthesis and fine chemicals synthesis, as well as in medicines, pesticides, dye intermediates, hair auxiliaries, etc.
L acid is used to prepare dyes and organic pigments, such as direct deep blue L, pigment purple sauce BLC, lake purple red CK, etc., and is also used to prepare photoresist photosensitizer 215.
ORTHOAMINOPHENOL:Organic synthesis and dye intermediates. Used to produce acid medium blue R, sulfide yellow brown, fluorescent whitening agent EBF, etc. It is also a test reagent for gold and silver. Absorption of this product through the skin can cause dermatitis, methemoglobinemia and asthma.
2,6-Dihydroxytoluene, also called 2-Methylresorcinol in English. It is a white solid under normal circumstances. It has a certain Chemicalbook solubility in water and its aqueous solution is acidic. Soluble in common organic solvents. 2,6-Dihydroxytoluene is a phenolic compound that can be used as an intermediate in organic synthesis and fine chemicals synthesis, as well as in medicines, pesticides, dye intermediates, hair auxiliaries, etc.
It is mainly used for the synthesis of pyrazolone antipyretic and analgesic drugs such as metamizole, antipyrine, and aminopyrine; it is also used for the synthesis of pyrazolone acid dyes such as acid medium date red BN, permanent yellow G, color film dyes, and pesticides. and other intermediates of fine chemicals.
It is an important dye intermediate, mainly used to manufacture azo dyes and sulfur dyes, and can also be used to produce fur black D and rubber antioxidant DNP, etc.
It is mainly used for the synthesis of pyrazolone antipyretic and analgesic drugs such as metamizole, antipyrine, and aminopyrine; it is also used for the synthesis of pyrazolone acid dyes such as acid medium date red BN, permanent yellow G, color film dyes, and pesticides. and other intermediates of fine chemicals.
1,3-Benzenediol of Physical Properties
Melting point and boiling point
1,3-Benzenediol has a melting point of 129-133°C and a boiling point of 283°C (litre).
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Density
1,3-Benzenediol has a density of 1.223 g/mL at 25°C. 3. Refractive index: 1,3-Benzenediol has a refractive index of 1,3-Benzenediol at 20°C.
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Refractive index
1.537 at 20/D. 4. Solubility: 1.537 at 20/D.
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Solubility
Solubility in dimethylsulfoxide ≥ 43 mg/ml (282.62 mM).
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Appearance and properties
1,3-Benzenediol is a colourless to yellow to orange transparent liquid.
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Method and Process for the Preparation of 1,3-Benzenediol
1. Biological method
The biological method is the production of 1,3-benzenediol by microbial fermentation. Commonly used microorganisms include Escherichia coli, yeast and so on. The production process of biological method is relatively simple, easy to operate and environmentally friendly, so it is highly favoured. The specific steps are as follows
1) Mix carbon source materials such as glucose and corn starch with nutrients such as nitrogen and phosphorus sources to form a fermentation medium.
2) Inoculate the microbial strains into the fermentation medium and control the temperature, pH and other conditions to make the microorganisms grow and multiply.
3) The microorganisms will produce 1.3-benzenediol in the process of metabolism, and the product of 1.3-benzenediol with higher purity will be obtained by separation and purification.
2. Chemical method
The chemical method is the synthesis of 1,3-benzenediol by chemical reaction. Commonly used raw materials are acetaldehyde, hydrogen, formaldehyde, etc. The specific steps are as follows
1) Acetaldehyde is hydrogenated with hydrogen in the presence of a catalyst to produce butanol.
2) Butanol reacts with water under acidic conditions to form 1,3-benzenediol.
3) 1,3-benzenediol is separated from impurities by distillation and rectification to give a high purity product.
3. By-product recovery processes
In some chemical production processes, 1,3-benzenediol is produced as a by-product. By recovering these by-products, 1,3-benzenediol can also be obtained. The specific steps are
1) Collect the by-products containing 1,3-benzenediol during the production process.
2) Separate 1.3-benzenediol from impurities by distillation, rectification and other processes to obtain a higher purity product.
Precautions for the Preparation of 1,3-Benzenediol
Airtight working and full ventilation: During the preparation process, airtight operation and full ventilation must be ensured to prevent leakage and accumulation of harmful gases.
Operator training: Operators must be specially trained and strictly follow the operating procedures to ensure safe operation.
Keep away from fire and heat sources: The workplace should be kept away from fire and heat sources, and smoking is strictly prohibited to prevent fire and explosion.
Use explosion-proof equipment: Explosion-proof ventilation systems and equipment should be used to prevent vapours from entering the workplace air.
Avoid contact with oxidising and reducing agents: Avoid contact with oxidising and reducing agents during preparation to prevent unnecessary chemical reactions.
Pack and unpack lightly: Light packing and unloading should be carried out during transport to prevent damage to the package and to avoid leakage.
Equipped with fire-fighting equipment: The workplace should be equipped with appropriate fire-fighting and spill-control equipment to deal with possible emergencies.
What are the advantages of using 1,3-benzenediol?
Medical and skin care applications
◆ Treatment of skin disorders: Certain derivatives of 1,3-benzenediol, such as 1,3-benzenediol monoacetate, are used to treat skin conditions such as acne, seborrhoeic dermatitis, eczema and psoriasis. They may exert their therapeutic effects by inhibiting inflammation, reducing oil production or having antimicrobial properties.
◆Preservatives and disinfectants: 1,3-Benzenediol and its derivatives have antiseptic and disinfectant properties and can be used to protect the skin and mucous membranes from bacteria, fungi and viruses.
Chemical industry applications
◆ Chemical intermediates: 1,3-Benzenediol is an important intermediate in the production of a wide range of chemicals and can be used in the synthesis of dyes, spices, pesticides and other fine chemicals.
◆ Solvent: 1,3-benzene glycol monoacetate and other derivatives can be used as solvents to dissolve, disperse or dilute other substances in chemical processes.
Precautionary measures
◆ Irritation: 1,3-Benzenediol and some of its derivatives may cause irritation to the eyes, respiratory tract and skin. It is therefore important to wear appropriate protective clothing and to follow safe handling procedures when using.
◆ Toxicity: Although 1,3-benzenediol is considered to be of low toxicity in some applications, prolonged or large exposures may be harmful to human health. Therefore, its use and handling must be strictly controlled.
◆ Compliance: When using 1,3-benzenediol and its derivatives, it is important to comply with relevant laws, regulations and standards to ensure that their use meets environmental and safety requirements.
Preservative and Disinfectant
1,3-Benzenediol Monoacetate is a commonly used preservative and disinfectant in a wide range of products and environments to ensure their long-term preservation and prevent microbial contamination.
Solvents
1,3-Benzenediol is also used as a solvent in some cases and is capable of dissolving a wide range of chemicals, thus playing an important role in chemical production.
Pharmaceutical and chemical synthesis
In drug synthesis, 1,3-benzeneglycol is used in the production of a wide range of drugs. It can also be used in the synthesis of the new polyester PTT and as a pharmaceutical intermediate and starting material for the synthesis of new antioxidants.
Factors to Consider When Choosing 1,3-Benzenediol
1. Purity: The purity of 1,3-benzenediol is an important consideration when choosing a product. The higher the purity, the less irritating it is to the skin and the more effective it is.
2. Application: Different 1,3-benzenediol extracts have different effects and must be chosen according to your needs. For example, 1,3-benzeneglycol extract raw material is widely used in skin care products and cosmetics, which can enhance the moisturising property of the products, moisturise the skin, make the skin softer and smoother, and has antioxidant function, which can help protect the skin from the damage caused by environmental pollution and UV radiation.
3.Ingredient matching: 1,3-benzene glycol extract raw material can be used with other ingredients, need to consider the compatibility between different ingredients to avoid chemical reaction, affecting the quality of the product.
Proper Storage and Handling of 1,3-Benzenediol
Storage temperature
1,3-Benzenediol should be stored below 30°C to prevent deterioration.
Sealed storage
Ensure that the container is well sealed to prevent volatilisation and moisture absorption. For volatile 1,3-benzenediol, an oil or water seal may be used to minimise volatilisation.
Handle with moisture
1,3-Benzeneglycol tends to absorb moisture, therefore it should be stored in a dry environment and if necessary a wax seal can be used to prevent moisture absorption.
Avoidance of light
1,3-Benzenediol should be stored in a place protected from light to prevent chemical reaction and deterioration caused by light.
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Established in 2014, Hangzhou Reward has emerged as a leading player in the chemical industry, specializing in the production and distribution of a wide range of high-quality products.
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In the ever-evolving landscape of chemical solutions, our company stands as a beacon of quality, innovation, and customer-centricity. Since our establishment in 2014, we have continued to grow and evolve, adapting to changes while upholding our core values. As a prominent supplier of pigments, dyes, cosmetic ingredients, textile auxiliaries, and more, we are proud to be your partner in shaping a colorful and vibrant world.
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